Something Scary Is Happening In Biolabs - Annie Jacobsen

CChris Williamson
Cold & Flu/DiseasesBusiness NewsEnvironment

Transcript

00:00:00last time we talked was about how we could blow ourselves to death and this time we're talking
00:00:04about how we could infect ourselves to death which one's scary a nuclear war or biological war
00:00:10it's equally scary in completely different ways i think you know with nuclear war the response to
00:00:18that was so many people calling me up and saying like okay i read your book i just want to die
00:00:22instantly biological war is tricky and scary because you don't have to die instantly and then
00:00:34you have to wonder i wish i did that's the sort of bad news first that is there any good news with
00:00:43biological there is because it can be prevented i mean unlike nuclear war which is like a just an
00:00:50event that happens without warning it's literally called an event without warning
00:00:54biological war is event with warning and that warning window it's literally like 12 24 36
00:01:04hours max but that is the window of time when something can be done why do you think biological
00:01:09warfare receives so little public attention compared with nuclear war yeah i mean terrific question for
00:01:16starters biological war is illegal biological weapons are illegal and yet biological weapons exist including
00:01:26now today 21st century genetically modified biological weapons for extreme transmission hyper virulence
00:01:36and designed to defeat existing vaccines and countermeasures but it's illegal so no one has them except for they do
00:01:46is there something about it being invisible as well there's no smoke in the sky
00:01:50i mean that's what makes it incredibly sinister i think it's invisible it's silent and when
00:01:56you really just think of this simple idea that a biological weapon any pathogen really is a living munition
00:02:04it's alive and it's a bullet with a mind of its own and it's like with itself reproducing and so
00:02:13it's just go once it gets unleashed do you think bioweapons are the most underappreciated existential risk
00:02:21of the modern world well i came across this chart in the dod that really freaked me out when i was
00:02:27reading when i was working on nuclear war and it's like the weapons of mass destruction wmd threat
00:02:33spectrum and of course nuclear weapons are like at the far end of the worst most destructive but biological
00:02:41weapons are a very close second and even more frightening they are considered the most likely to occur
00:02:49and therefore the most dangerous and this has to do with you know laboratories doing defensive research
00:02:57on biological weapon countermeasures so there this is where you get really into a lot of
00:03:04you know sort of catch-22 very politicized debates which we're going to stay away from and just
00:03:12talk about it as like a or at least i am you know because it should no one should be for
00:03:18biological war what surprised you most about comparing the two nuclear war and biowar
00:03:29well equally shocked in in two lanes so nuclear war remember when craig fugate who's obama's former
00:03:36fema director told me that there is no plan for population protection in the event of a strategic
00:03:44nuclear attack because everyone will be dead i mean that was stunning to me because this is coming from
00:03:48the guy in charge of it equally stunning is that there is a plan for protection in the event of
00:03:57biological war but it's not for the population it's not for you and me it's for the government
00:04:03it's for a tiny group of government officials that will live out the attack or the incident by the
00:04:12way it doesn't have to be an attack it can be an accident but this is super creepy and people should
00:04:18definitely know about it and be very upset when they do let's start to creep people out there okay
00:04:23starting at the beginning how did we learn to engineer biotechnology what's the story yeah
00:04:29yeah i mean people talk about crisper now and you know the crisper cast sort of gene editing that's pretty
00:04:35much third or fourth generation gene editing so this the origin story of gene editing is 1971 in a
00:04:44laboratory in stanford at stanford university in stanford california and a nobel laureate named paul berg
00:04:52he won the nobel laureate for the work he did figured out how to create what is called a chimera
00:05:00pathogen so mix chimera is like that ancient greek idea of a monster made up of two different parts
00:05:07and berg figured out how to create recombinant dna that is the real fundamental word for gene editing
00:05:15and that was way back in 1971 recombinant recombining absolutely okay it's just like it sounds so much of
00:05:21this is just like it sounds okay you know and that's where it all began and you know then then there's
00:05:27the short and long version of how we got where we are now what's the argument for doing genetic
00:05:33engineering the argument like all dual use technology is like you can use it to heal you can use it to
00:05:41harm i mean this is true of every technology going back to when humans invented or discovered fire right you can
00:05:50like cook your meat and not get trichinosis or you can burn down the next tribes
00:05:57you know over um every every technology has that same component and so with with bioengineering the idea
00:06:05is and certainly now very specifically to where we are today is about okay we we will work with dangerous
00:06:13pathogens to genetically modify them so that if a dangerous pathogen is released we will know how
00:06:24to create a medical countermeasure for it you see the chicken and the egg and the catch 22 offense and
00:06:31defense are contained within the same system absolutely and this is where huge divides occur and this is where
00:06:39the term called gain of function which you know 99.99 of the planet had never heard of until the coveted
00:06:48pandemic because now becomes such a hot button issue gain of function is literally like it sounds you work to
00:06:57genetically modify a pathogen to give it new functions to you know so that it gains function and the idea of
00:07:05that is that okay just in case someone releases a biological weapon we will know how to go up against it
00:07:11and this is the big debate about covet which do you think that covet from a
00:07:20biological weapons safety pandemic standpoint do you think that was kind of an important thing to
00:07:28happen in some ways do you think it was a positive or a negative i mean that's you know it did happen
00:07:35and here we are now and i think the separate from what anyone thinks about you know natural origin versus
00:07:42lab leak the two most important lessons of covet is one that we are extremely ill prepared for a pandemic
00:07:52despite the fact that in the u.s billions of dollars are spent every year to to deal with exactly that
00:07:58kind of thing um that's the first lesson and the second lesson is that the pandemic completely fractured
00:08:09public trust around science around public health officials uh around politicians and so this fracturing
00:08:20is incredibly dangerous and i believe is also where the solution lies i mean that's like a real long
00:08:26stretch to try to get there but it must happen because it is such a dangerous position and if we really
00:08:31get into it and eventually talk about the russians biological weapons program of the cold war
00:08:37uh upon which some of the the pathogen that gets deployed in my scenario is built then you're really
00:08:42looking at the idea of soviet russia was to ruin america to gut america by creating by fracturing public trust
00:08:54the thing that's crazy covet feels really uh symbolic i think of covet is basically a vaccine that went
00:09:06wrong covet itself was a vaccine that went wrong because we could have been given the a small non-fatal
00:09:12dose of a future risk that would have alerted us to all of the ways that we were ill prepared so that we
00:09:18could be better prepared for it in future but because of the way that institutions and the medical industry
00:09:25and communication and lockdown and trust were all degraded and and really really damaged you're right
00:09:32it's done two things at once it's taught people what a super spreader event is it helps us to understand
00:09:38the importance of masking and ventilators it's reminded us how ill prepared we are all of those things
00:09:43should prepare us better for the one in future however the current if there was a pandemic that
00:09:51got released tomorrow the amount of pushback from the populace would be huge because nobody has trust
00:09:57for any more jared can you do a search for me please search um toby ord ord the precipice
00:10:07risk chart it should be an image and um this is the thing that's insane the fact that we were so ill
00:10:14prepared i'm pretty sure that the precipice came out in 2019 uh so before covid and in order to write
00:10:21the book and to have the research and to be able to get to the stage where yeah top left that's it
00:10:24that's that's the one existential uh catastrophic risk via asteroid or comet super volcano stellar
00:10:31explosion so natural risk it says chance within the next 100 years one in 10 000 that's of all of them
00:10:36stellar explosion is that one in a billion one in a billion uh so we we should be safe from that nuclear war
00:10:43one in one thousand climate change one in one thousand other environmental damage one in one thousand
00:10:49naturally arising pandemics one in ten thousand now we get into the real shit engineered pandemics
00:10:55one in 30 30 in the next hundred years unaligned artificial intelligence one in ten
00:11:00unforeseen anthropogenic risks one in 30 sets unknown unknowns and other anthropogenic risks that's
00:11:05a catch-all bucket total anthropogenic risk over the next 100 years a one in six chance and
00:11:12this is the difference between what was the word you used global catastrophic risk global okay so
00:11:18the difference i think between global catastrophic risk and existential risk so existential risk is
00:11:23categorized as permanent yeah unrecoverable collapse permanent unrecoverable collapse because
00:11:31nuclear war as a proper x-risk it's usually pretty easy to recover from there is a way that
00:11:37you can recover from it as a civil as a civilization like to get everybody with nuclear weapons that would
00:11:44need to be set in the sky that would need to be you because you only need like 500 or a thousand humans
00:11:50and then you're able to come back the bioweapon thing is even scarier because that is able to make
00:11:57every person it is a bullet with legs that can self-replicate i wrote biological war a scenario not
00:12:04biological war the only scenario and in my acknowledgements part of the book i mention
00:12:10how in some of my interviews and i'm talking about like with david relman sort of top level white house
00:12:16advisor to many presidents told me about pathogens that literally can do exactly that and i made that
00:12:24decision not to go with that kind of a threat although you know the case fatality rate of the plague weapon
00:12:32that is engineered in the scenario i write is a hundred percent case fatality rate so if you get it
00:12:38you die okay but there are i won't get too far ahead of the weeds but that chart is amazing yeah and it really
00:12:46is kind of on point of what we're talking about here and i love your analogy that covet is theoretically or
00:12:52philosophically yes you know sort of a medical countermeasure gone wrong correct what it is
00:12:58because if you think about it as it was a poison of the mind as well it could have been a cautionary
00:13:04tale the case fatality rate on covet was one in a hundred that is a lot of people died but that's not
00:13:12at the level of what an engineered pathogen is most bioengineered pathogens are designed
00:13:19to move toward 100 case fatality rate if you get it you die who were the first people to start using
00:13:27this as a weapon because obviously you've got recombinant dna we've opened up this entire world
00:13:32this technology who were the first people to really turn it on an industrial scale into becoming a
00:13:39weaponized threat that was the soviets right so backing up once first of all in the cold war
00:13:45we had biological weapons programs the u.s had a robust biological weapons program offensive and
00:13:51defensive i've written about it in other books so did russia uh the soviet union in 1969 president
00:13:59nixon renounced america's biological weapons program entirely for reasons that are debated doesn't matter
00:14:05that was it it's over destroy them all took 219 weeks to destroy a treaty was signed around the
00:14:11world the bwc biological weapons convention treaty biological weapons are too dangerous they're called
00:14:19repugnant to the conscience of mankind in the preamble right so it's this very lofty idea that like
00:14:26you know we will not do this and everybody signed the treaty and not including the soviets including
00:14:33the soviets fucking soviets and in now we know because of a defector and i get into this in the
00:14:38book because it's very interesting i interviewed the british um intelligence officer who first found
00:14:44out about the whole soviet program not until the late 80s did america did the cia did british intelligence
00:14:51have any idea that the soviets had this colossal program they stole our recombinant dna technology
00:14:59i mean good old ip theft back in the in the 70s and they were the china of the 70s and they began this
00:15:06biological weapons program they called it our manhattan project and we had no idea now bring us to the
00:15:13present day just to deal with some facts about who has biological weapons according to the state
00:15:19department russia has a biological weapons program this is on the record and this is a pretty big deal
00:15:26and their position is that the soviet program was not dismantled as had been promised when the wall
00:15:33came down but rather absorbed and the state department has the same position about north north korea
00:15:42that they have a robust biological weapons program and then their position on china and iran is they
00:15:48are questionable which is like euphemism subtext for they have biological weapons programs has the
00:15:54state department admitted to having them themselves we do not have a biological weapons program how much
00:16:00do you believe that officially officially but but okay but well let me just say this what we do have
00:16:10and what we have had in the past is a defensive program and so i've interviewed i interview some
00:16:19really interesting people for this book including like the top dogs in this world okay and and people
00:16:26who run war games at the pentagon for how this would go down and most people in the business of preventing
00:16:33biological war in the united states believe that gain of function is evil that word was used with me and
00:16:42and and and have also said gain of function is a euphemism for
00:16:49biological weapons engineering how many people are opposed to enhanced interrogation and yet guantanamo
00:16:55base still happened you know i i think what and this this speaks to the the the lack of trust right in
00:17:02absolutely in in government that and also there's a bit of me that thinks i want to be on the side that
00:17:09has them i don't want to be on the side that doesn't have them i'm aware that there can be lab leaks i'm
00:17:13aware bsl 3 and 2 and you know if one guy's got a gun i want a gun the issue with the biological weapons
00:17:24is that nuclear weapons
00:17:29take out biological weapons nuclear weapons and in fact there are secretive this is this is not annie
00:17:39reporting classified information this is annie speculating in the affirmative i'm not going to
00:17:44put the nose on i'm going to go go full with this right no no no i mean this is like um so new there
00:17:52have been moments when there have been leaks that is understood that the defense department is trying
00:17:59to get a presidential emergency directive to be allowed to use nuclear weapons preemptively
00:18:06against a biological a known biological weapons facility and whenever this gets leaked it causes an
00:18:12uproar so i would assume given what i know about national security that that that directive still exists
00:18:21yeah and the reason why that exists people say well why wouldn't you just take it out with
00:18:26conventional explosives conventional explosives have this strange effect on germ labs whereby the
00:18:35explosion they just atomize it push it and it pushes it out faster so it goes you see so it's
00:18:41non-effective you need to incinerate it and the nuclear weapon has a temperature that incinerates it and a
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00:19:39that's drink lmt.com what a wisdom i remember talking about sort of who first started using them
00:19:48some of the medieval stories that i've read about during sieges they would put dead bodies and refuse
00:19:54and diseased animals into the water supply of a castle so it's not like this is something that's new
00:20:00catapulting trebucheting um diseased animals over the walls to see if they can send germ they understood
00:20:09not maybe the mechanism but they understood the outcome which is these people are going to consume
00:20:13this if we put stuff in that's dirty or something infected in some way it might hurt them so it's
00:20:21not uh new in terms of idea it's only new in terms of sophistication the sophistication component when
00:20:27it comes to genetic engineering is what's so dangerous because it only takes a minute hopefully
00:20:34reading my book or just having this kind of conversation to get to the real heart of the
00:20:38matter with your x-risk with and what the defense department calls a near extinction level event that's
00:20:46you know nuclear is different that's like extinction level events so we differ on that
00:20:51but biological is near extinction that group of government officials is going to stay alive according to
00:20:58planning but the difference um in that is that you know biological weapons are once they
00:21:08propagate there's no stopping them and the number one reason is airborne airborne so many different
00:21:16pathogens ebola except they're not airborne but if something's airborne you and i are talking
00:21:23we're both infected what are the elements of the perfect biological weapon airborne is number one
00:21:29okay number that would be the transition number one transmission 100 transmission so what's interesting
00:21:35about covid and i just use this sometimes it's a great example because everybody was remembers covid
00:21:40those of us that you know live through it that aren't a baby um and there was for the first three months
00:21:47of covid the who was sending out tweets that said covid is not airborne not in full capital letters
00:21:57they believed that covid was transmissible through you know me passing this to you and it's called a
00:22:05fomite not how it's not how it works some pathogens are some pathogens are absolutely but covid but covid
00:22:13wasn't and they were convinced it wasn't airborne and it was airborne there was 8 000 people already
00:22:20with covid before the whu made made us change that statement and this they were not doing it to be
00:22:27nefarious they were doing it because they didn't know there is so much uncertainty in biology so much
00:22:35uncertainty it's probably part of the reason why the u.s got rid of its biological weapons program
00:22:41the defense department likes to know you can measure how many people you're going to kill with a bomb
00:22:47it's called a circular damage issue and you don't know with biology and so the defense department if
00:22:54they can't control it they don't like it yeah i remember people were wiping down amazon parcels there
00:23:01was even a a rule added into pickleball where you could do a paddle serve so as the ball came toward
00:23:07you could scoop it up on the paddle flick it in the air and hit it because people were that worried that
00:23:12maybe the other person had picked the ball up and if i picked the ball up and then up so uh okay
00:23:16so elements of the perfect biological weapon first one is it's airborne yes transmissibility transmissibility
00:23:22is airborne what else what what how else would it be constituted virulence right so it's it's case
00:23:29fatality rate covid as we said earlier one percent so hundred people get covid one dies that's a pretty
00:23:37low case valid case case fatality rate hantavirus recently in the news um high 30 percent case fatality
00:23:46rate so that's a lot of people if you write the flu the seasonal flu by the way is 0.1 percent
00:23:54pneumonic plague what's that which okay we you know we all know bubonic plague
00:24:01pneumonic plague is the aerosolized version of bubonic plague bubonic plague a flea
00:24:08from an infected flea bites you you get bubonic plague
00:24:14pneumonic plague it gets into your lungs and it becomes aerosolized pneumonic plague has a case
00:24:20fatality rate of 100 unless you get antibiotics into your system within 24 hours not 25 hours
00:24:31first 24 hours you get antibiotics you have a chance at living if you don't you die 100 100 100 what's the
00:24:40incubation period of pneumonic plague the natural incubation period is between one and three days
00:24:48sometimes five again this is there's so much ambiguity in mother nature genetically modified plague
00:24:58one day so imagine a situation where this is what i this is the pathogen that i choose in the scenario
00:25:06because it is what the defense department fema hhs cdc who is probably the most afraid of it's called a
00:25:16select it's called a tier one select agent it's one of the most likely to be used and it's a 100
00:25:25killer and now imagine if you could genetically modify that to evade cure so imagine if antibiotics no
00:25:32longer work and what i'm saying may sound like science fiction horror except for it's precisely
00:25:40what was at the center of that soviet biological weapons program of the 70s and 80s that we talked
00:25:47about a moment ago that's what they were engineering they were engineering a super plague weapon did they
00:25:52achieve it questionable but that think of how many decades ago if they didn't do it then they certainly
00:25:58have done it now here's was the exact line from dr christopher davis who interviewed the first russian
00:26:04defector who told him about the super plague weapon he said they wanted to keep thinking of the soviets
00:26:11planning a biological weapons attack against america they wanted to kill all the people and leave
00:26:19the infrastructure intact which you don't get with nukes you get rid of the people but you also have to
00:26:24rebuild the city imagine just taking all the people out and just marching in and everything that was
00:26:32theirs is now yours yeah it's just like pressing a delete button on all of the humans i mean you've
00:26:38got to get rid of the bodies yes that's a small price to pay if you wait long enough they sort of
00:26:43disintegrate what was the goal of the soviet scientists do you think it was primarily casualties or
00:26:49something more psychological very good question it was actually both it was a two-fold idea it was
00:26:57this create this mass death that we're talking about and remember maybe not the soviet scientists
00:27:04it was the politburo the sort of planners behind it the military the soviet officials that just hated the
00:27:12their american enemy so much that they came up with the most diabolical plan possible and it was exactly
00:27:19that it was just kill everyone but also create such mistrust within the medical establishment they
00:27:27wanted to out fox antibiotics which normally will kill plague the bacteria is called yersinia pestis
00:27:36and they wanted to specifically send america back to the sort of you know pre-antibiotic era
00:27:46and have all the people have completely lost trust in the medical establishment how did we find out about
00:27:51the soviet weapons program the program was huge and it was secretive and no one knew about it from
00:27:59you know until 1988-89 and then one of its leading scientist engineers named vladmir poseshnek
00:28:09had a moral crisis and he was a rare soviet scientist who was allowed to leave
00:28:17russia to go buy equipment for the biological weapons program in france
00:28:23and that is where he went he decided to defect and tell the west so he went to the embassy he actually
00:28:34went to the canadian embassy first and they didn't believe him and they sent him away and he went back
00:28:39to a phone booth and he called the british embassy they took him very seriously picked him up in a car
00:28:46and a day later he was sitting in london in a safe house across the table just like you and i are now
00:28:54from dr christopher davis who was the own pretty much the only guy assigned to biological weapons
00:29:02in the british intelligence because there were no biological weapons there weren't supposed to be
00:29:07so he was this young surgeon commander and he knew a lot about biological weapons
00:29:12and i've interviewed him at length for the book imagine him learning about this and learning about
00:29:17the super plague weapon and going and then the british told their american counterparts at the cia
00:29:25it was verified and that was it verified we sent so davis and another colleague went to the cia in
00:29:35and langley had a discussion with them told them everything that possession i could said um these
00:29:43guys are mds and phds and you know the cia was like okay well we have to verify it ourselves they sent
00:29:48joshua letterberg who's a very famous nobel laureate to the uk to interview possession himself
00:29:56and dr davis was there in that room and he said letterberg was like he's the way he said it was
00:30:03the scales fell off his eyes oh my god like not only what have they done but how did we not know this
00:30:13they were manufacturing tons of plague weapon tons of smallpox weapon and the system the delivery systems
00:30:23were such in those days they weren't airborne truly airborne they were going to be delivered you know on
00:30:28like sort of low flying cruise missiles and dropped there was a whole weaponization that had to happen
00:30:34in capsules in bombs or in like you put they had they had engineered and actually correctly
00:30:41engineered that was part of the verification process creating warheads that could survive this incredible
00:30:47heat um and their delivery systems work but that those were never used okay so that's how weapons can be
00:30:56used to attack but surely everyone also needs to build bio defenses as well and this is the big conundrum
00:31:02this is there's a paradox there right yeah the effort to defend against biological attacks results in more
00:31:07labs being built which increases the opportunity for a biological catastrophe because you don't just have
00:31:14purposeful deliberate leaks or attacks yes you don't just have purposeful attacks you also have
00:31:19accidental leaks absolutely and maybe no one would be crazy enough to use a biological weapon because they
00:31:26know about blowback now you know what happens with the pandemic except a terrorist organization you know
00:31:34that doesn't value life shall we say in this certainly in the same manner as you know the west
00:31:40um but the lab accidents and the lab leaks are a very serious concern and should be but let's talk
00:31:49about labs for a minute because i think it's very interesting to look at numbers so we just spoke of
00:31:55like in the 90s you know the u.s finds out about the soviet program clinton makes the use of a biological
00:32:02weapon a death penalty event uh offense the system really vamps up the cold war is down now there's a
00:32:09new enemy i mean the the cold war is over the walls down now there's a new enemy it's definitely
00:32:13biological weapons terrorists start to enter into the fold and then 9 11 happens and when and most people
00:32:21forget or aren't old enough to remember that just a few weeks after 9 11 there was an anthrax attack
00:32:28against the senate yeah and that moved the biological pharmaceutical biotechnology biodefense industry
00:32:38call it what you will into high gear and that's where the a whole new system of science unfolded
00:32:47to work on exactly what you're talking about medical countermeasures in the event of a biological attack
00:32:52and so for example there were two bsl4 labs that's the highest maximum containment biosafety level four
00:33:01the you know the zoot suits the spacesuits and the hose with the air and you're working in an autoclave
00:33:06and there's like it's very it's an autoclave you know all your hands are in yeah gloves and the
00:33:12path like an empty fish tank with with gloves we've seen it in movies yeah that's bsl4 there were two of
00:33:18them defense department had one at fort dietrich civil sector cdc had one in atlanta after 9 11
00:33:2815 bsl4 labs and over a thousand bsl3 labs bsl3 is just one step down that's where you work on plague
00:33:38hantavirus what you work on in bsl4 if you've got plague and hantavirus and bsl3 and this was very
00:33:44interesting to learn about this because i had that same question bsl4 is absolutely no known cure it's
00:33:51ebola it's marburg it's nipa no known cure and i don't know marburg or nipper they're virus
00:33:59they're viruses some of them yeah mother these are all mother nature so and then the plague remember
00:34:07plague should be um able to be the plague bacteria should be killed by by antibiotics when you get
00:34:17into genetic modification now we have a different story um hantavirus should be able to be contained
00:34:22but yes it's a very good question about what's the difference between bsl4 and bsl3 if you're working
00:34:28gain a function in them but these labs blew up in number and they also did around the world how
00:34:39how many viruses are you aware of that have been created or bioweapon bioweapon
00:34:46analogues have been created from scratch is there such a thing that great question that's called
00:34:52synthetic biology and that is very new like third generation recombinant dna crispr where you yes
00:35:02you can create something type it in does not exist in mother in in nature or that is a chimera uh gain
00:35:10of function of an existing thing that exists and that's not necessarily well that's sort of at the
00:35:15edge of synthetic biology yes it does involve synthetic biology but you can actually create
00:35:20a completely new blank slate and that is that's where you're getting into the area and and certainly
00:35:25with ai are you aware of any of those that have been made that is so incredibly classified i mean
00:35:33i would have to get your entire body of work seems incredibly classified well no i mean this is what's
00:35:39interesting people sometimes say to me annie how do you get classified information i don't my sources
00:35:44would be in prison i name my sources so they're taking me up to the edge of what can be known
00:35:52when we get into devolution which is the program to save you know a small group of individuals when
00:35:58everyone else is dying and mass anarchy and insurrection unfolds across the united states and
00:36:02everywhere i can that is a classified program devolution spooky evolution devolution okay classified
00:36:11program but the name has been declassified so like five years ago you can't listen to my new album but
00:36:19i'll tell you what it's called or the river right yeah you know um i'll tell you what it's called but
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00:37:33aware what are the most risky or controversial experiments that have happened in bioweapons so far
00:37:40well okay so technically they're not in bioweapons they are in you know biological countermeasure pursuits
00:37:47okay because remember biological weapon engineering is illegal um just a few basic ones that are good
00:37:55to know and also how old some of this technology is is like right around 2000 2001 there was a mousepox
00:38:02experiment it was one of the first ones so um in australia they took scientists there just wanted to
00:38:10experiment and see and they took mice that had been vaccinated and they gave them mousepox which is
00:38:18similar to smallpox to see if they could defeat the vaccine and they did so that was a terrifying moment
00:38:26in bioengineering because you realize you could defeat a countermeasure that's where you're you know
00:38:33engineering something to evade cure that's incredibly dangerous and then like 10 12 years later there was a
00:38:41there was a modification on h5n1 it was called the ferret flu um experiment and
00:38:50the scientists working on that made h5n1 airborne before that it was not airborne so
00:38:57there's a there's a lesser airborne version which is um respite like con like if i if you and i are
00:39:04talking have you ever been at a party with someone loud music and by and they spit on you
00:39:09that's called droplet transmission right and you know we've all had it happen and you kind of like
00:39:15go right it's just gross but it's it happens definitely never rub your eye
00:39:21never rub your eye or your nose okay or put your finger in your mouth okay those are the three that's
00:39:28how droplet transmission occurs okay eye nose mouth right okay um that's not that's not airborne
00:39:37airborne is aerosolized airborne is just it's in the air and it's floating in the air and it can stay
00:39:42in the air um and so what scientists did in that 2012 experiment is they made something that was
00:39:50droplet transmission and that's you know if i back way up and you're over there and you're not leaning
00:39:55in close to talking to me i'm not going to get your if you're realistically that's what those big
00:40:02plastic welding shields that people were wearing during covid that's really all that they would
00:40:06have been good for precisely and that's what the the mask does is it just if somebody spits on you
00:40:11it's it's a layer presumably this is kind of um necessary but not sufficient like if something is
00:40:18aerosolized it also has to be transmissible through saliva like through droplet absolutely because
00:40:24droplet is basically liquidized aerosolized yeah that's just a fact like if you gave in in my scenario
00:40:30somebody gives somebody cpr sayonara you know and that has to do with how quickly you're going to then
00:40:37be infected yourself right because this is again squishy biology it's not perfect it's one of the major
00:40:43problems with covid with your analogy of how it just became so terrible because health officials refused
00:40:50to say you know what we don't know we don't know yet they couldn't say that instead they said covid's
00:40:56not airborne and then later they had to backtrack well imagine all of us that didn't know better
00:41:02we're saying why are they telling us x when it's really y yeah yeah you're the boy who cried wolf so
00:41:07do you think it's fair to say that biotechnology is sort of the most powerful but also least controllable
00:41:12technology that we've got as a civilization i would say nuclear weapons are the most powerful
00:41:17just in terms of destruction and in terms of temperature right by all means but biological
00:41:24weapons are the most dangerous for precisely the reason you say because they are except look there's no
00:41:30barrier to entry nuclear weapons are control first of all you have to have uranium or plutonium and that
00:41:37is pretty hard to get a hold of very difficult then you have to have a nation state that can afford that
00:41:42and then you have to have a delivery system you can't just drop a nuclear weapon in a field
00:41:48you have to deliver it that is incredibly expensive the barrier to entry is high it's why thank god we have
00:41:55not had a nuclear event since the first two bombs were dropped in world war ii biological weapons have no
00:42:03barrier to entry anymore you can essentially engineer a pathogen with very limited biology in your basement
00:42:12the desktop printer it's terrifying it's terrifying and everybody in the business of biological weapons
00:42:17knows that and the solution must be to be informed and it must be to on have a you know have a capacity
00:42:26to understand what can really happen i guess you you looked at the um green amber red system that's used
00:42:34for desktop uh uh uh uh is it biosynthesizers so i remember learning this from uh the end of the world
00:42:42with josh clark which is my favorite limited series podcast from like eight years ago in it he's talking
00:42:47about how bioweapons now you can have these uh tabletop synthesizers and uh in order to synthesize
00:42:56different um dna structures they get run through a library that stress tests what it is that you're
00:43:03trying to synthesize and you can do green all day long uh amber needs a level of clearance and if you do red
00:43:12there is you can't do it first off and there is a like fbi come and kick your door down but
00:43:20nick bostrom's got this really interesting experiment he's from the future of humanity institute the same
00:43:24that toby is and he says it's only due to sort of luck of chemistry and physics that you can't create
00:43:32an atom bomb by putting sand in your microwave by combining something that is very readily available
00:43:38with a technology that is easily accessible and the fact that that's not the case like hooray but that
00:43:45it didn't need to be that way it could be the case that there could be a type of technology there
00:43:50could be a type of destruction which is enabled by an easily accessible technology with or without some
00:43:55easily accessible resource uh and yeah as we democratize information and technology each time
00:44:03that you do that he refers to it as drawing balls out of an urn have you heard this example before
00:44:09i have so you have an urn with an unknown number of balls in and for everyone that you draw out that's
00:44:14like technological progress so you put your hand into the urn and you draw a ball and sometimes they're
00:44:19white they make the world a better place hooray pull out another one and it's white makes the world a
00:44:24better place and then you pull out one and it's gray and it makes the world a better place but it also
00:44:28makes it a more dangerous place better place more dangerous place but inside the urn of an unknown
00:44:33number of balls or an unknown number of black balls if you pull one of those out it's game over and
00:44:39that is the kind of technology that as you make progress this is a guy who is from the future of
00:44:43humanity institute philosophy he's the most cited philosopher under the age of 50 in the world this
00:44:50guy bostrom bostrom bostrom yeah he's yes if you pull out the black ball but you don't even need to
00:44:57pull out the black one if you just pull out enough gray ones the risk begins to combine to the point
00:45:02where it's very dangerous okay let's war game out your nightmare scenario day one what happens explosion
00:45:10at the vector lab in russia and the reason that i chose that is why i chose many plot points in the
00:45:18scenarios it happened once before in 2019 there was an explosion at the vector lab vector is the bsl4
00:45:26facility where the a majority of the soviet bioweapons program occurred back during the cold war where
00:45:33is it it's in just outside of novosibirsk siberia okay and so that may sound like the middle of no nowhere
00:45:43it's actually in a small sort of village a science city called koltsovo eight miles from novosibirsk
00:45:51siberia it's you know people are like wait siberia is that a real place it is okay sounds far away
00:45:57it's the third largest city in russia after moscow and st petersburg 1.6 million people
00:46:07and most bsl4 lab or many bsl4 labs by the way are just right in the middle of some of the largest
00:46:14popular population centers in the world tokyo south africa atlanta right so that's how it begins i have
00:46:20an explosion in the lab but unlike what happened in 2019 where there was no release as far as anyone knows
00:46:28there is a release of a pathogen and it's pneumonic plague and it's genetically modified pneumonic plague
00:46:37and i take the reader through the military system of systems as as i have spent my career working to
00:46:44understand all that to see how the dod reacts and to see how and when the president will be told and to
00:46:53see how and when the different agencies get involved and to me that was just an extraordinary you know
00:47:01learning curve and a sort of like whoa along the way with the number one thing leading the charge that
00:47:09every sort of expert in any of those agencies told me was annie if you can stop something with 12 to 24
00:47:15hours 12 to 24 to 36 hours if you can stop it in his tracks you can prevent a pandemic but of course
00:47:22because biological weapons are illegal no one wants to admit they have biological weapons in their
00:47:28freezers and so those nations immediately going to try and cover it up or deny it and that is the
00:47:34natural response across history to just if there is an unnat you know there was a famous case in
00:47:41sverdlosk in russia in 1979 where they were weaponizing anthrax they were milling it into powder anthrax is an
00:47:49interesting pathogen because it's called a dead end host right so if you get anthrax it's not
00:47:54transmissible you get in your lungs and you die but you can't it's not airborne but it's like a super
00:48:00killer and for whatever reason it was sort of favored you know pathogen of the cold war we had an anthrax
00:48:07program too so there was a there was some guy some you know engineer in the garrison 19 where they were
00:48:14milling the anthrax into tons of weapons forgot to change the air filter and it got out and it killed
00:48:23a hundred people in the town and so the soviet politburo you can imagine the generals with their
00:48:28tall boots came in and were like it's contaminated meat
00:48:35and it was you know it was an escape it was a lab escape and they denied it for decades now it's
00:48:41known to be this kind of a situation so a lab leak a lab accident is really a very dangerous situation
00:48:51would the us be aware because presumably they've got satellites that see if they'll have an idea about
00:48:57where potential labs are yes they'll be trying to track hey has there been some sort of kinetic event
00:49:04that's occurred there and what's the process of what you're absolutely right i mean with nuclear weapons
00:49:10we have satellites parked in geosync over all the facilities to look for that launch in the first
00:49:18second that it happens and we see it and we know it lab a lab accident is different it's a different
00:49:23kind of explosion but they measure it from space they know it's not a icbm launch it's an explosion and
00:49:30the reason specifically why they have eyes on the vector lab is not just because it's like a super
00:49:37dangerous lab that's known to probably have all the bioweapons but because it's just a few miles from
00:49:43an icbm facility in novosibirsk so the defense department officials i interviewed said absolutely
00:49:49annie we'd have eyes on it we'd know it and we'd call it in and but what do you do what do you do
00:49:56you know you you reach out to moscow through your state department people i spoke to state department
00:50:04officials that work in the business of counter-proliferation this is sort of like a fancy
00:50:09word for saying trying to stop you know biological weapons in their tracks they would make an overture
00:50:17no response so now you're met with the do we drop the nuke or not question you are met with that
00:50:24because you only have 12 hours 24 hours probably at most yeah and that you know that is a scenario that
00:50:32we've seen in hollywood movies it's actually could very plausibly be a real scenario but
00:50:37who's going to do that because it's almost certainly going to trigger a nuclear exchange
00:50:42certainly not interesting to think about the way that nuclear weapons work at least the old
00:50:46the old style ones where you had uh uh well even the new style ones right the the h-bomb you have a
00:50:51trigger and then that is the explosion and in this you would have a trigger before the trigger and the
00:50:56trigger would be the bioweapon leak that would cause the nuclear attack which would also have its trigger
00:51:03inside of a trigger and then you're talking about what's called a wicked problem a wicked problem in
00:51:11defense department nomenclature is a problem that only creates more problems with its solution and by the
00:51:18time you deploy the air quote solution new problems have been created
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00:52:28really difficult to determine whether or not a biological release has happened
00:52:33all of this machinery spins up any host nation that's it and dropped the ball doesn't want to admit it
00:52:40yep day two what happens so back up for a second because i'm going to tell you some really interesting
00:52:47intelligence collection methods that are wild to think about so we you know that so the the entire
00:52:55intelligence community in the united states at this point in a scenario is now focused on did what is
00:53:00are people dying that's what they need to find out or what is the what is the russian government doing that
00:53:06makes us think they know there's been a lab escape yeah and so there's nsa listening to the sigint there's
00:53:11nro looking down so nro is the eyes nsa is the ears what's nro uh the national reconnaissance office
00:53:18organization so that's space satellites and then you have a really interesting um collection component
00:53:26called mazant which is measurement and signal signature intelligence and it's sniffing so we have sensors
00:53:39or maybe we have sensors i'll put it that way in facilities i mean i'm talking like sewer pipes maybe the
00:53:48walls on signs you can put amazing sex sensor on anything that moves it could be on a drone
00:53:56it could be in a vehicle it could be in a sprinkler system and that is sniffing
00:54:04for a level and the intelligence officers are looking for change so when when the signatures change and
00:54:12that would usually have to do with chemicals that would be used by the russian government that would
00:54:17be deployed to try to mitigate the aerosol release that's interesting what sort of chemicals can you do
00:54:23to that try to mitigate this i write them in the book they're a little hard to pronounce
00:54:28what do they achieve well it's it's like a it's like a a dumb dumb version of ammonia right so imagine if
00:54:36if a pathogen spilled on this table you know get out the like you would try and clean it up
00:54:41with rubbing alcohol ammonia well these are like industrial versions of those drugs so and you see
00:54:48spraying you saw that i remember when covet happened in iran they were there were trucks going down the
00:54:55street with hoses and and people were just spraying you know government people were spraying the streets
00:55:03with an unknown chemical we i don't know what it was i'm sure somebody in the you know intelligence
00:55:08community knows you can do that in a totalitarian-esque country because no one has a say you can't do that
00:55:17here in austin people would be like they would freak out yeah yeah but the in a place like russia you
00:55:23could do that and that's being looked at so i take the reader through these different you know you see
00:55:28this entire billion dollar industry go into effect to try and determine has there been a lab leak are
00:55:35people dying uh-huh and if so how but the number one thing that has to be identified is what is the
00:55:42pathogen is it a virus is it a bacteria very interesting distinction that most people don't know a
00:55:48pathogen is a germ that will kill you germs are germs we all have germs with germs in our guts but a
00:55:53pathogen is a dangerous deadly germ potentially potentially virus bacteria plague is bacteria not virus
00:56:02right what's more deadly it depends i mean plague without um a flu is a virus you get the flu it's not
00:56:10it's the case fatality rate is 0.1 it's not that deadly you get plague that's genetically modified to
00:56:17evade antibiotics it's a hundred percent death so it it depends what's the most deadly virus that you're
00:56:25aware of i mean ebola is ebola marburg nip they're up there in terms of if you get ebola
00:56:36your chances of living are very low now medical countermeasures have been developed
00:56:43from the 2014 variant of ebola there's a there's a medical countermeasure called zmap and it was
00:56:49given to two nurses in texas for example that i write a little vignette in the book about it and that
00:56:56was a medical countermeasure and they did not die of covet the host died didn't have it but the mutated
00:57:03version of ebola that we're seeing right now in the congo zmap doesn't work because it's a variant
00:57:10right no reason to believe it's genetically modified mother nature does her own modifications
00:57:18that's the nature of evolution we talked about uh incubation period am i right in saying that that is
00:57:23the amount of time that somebody can be exposed and it's in their system before they show or feel
00:57:29symptoms is that correct absolutely okay in your scenario how long is that incubation period
00:57:35it's very small it's very squishy meaning one to three days depending on your dosage so i told you
00:57:41the guy who gave cpr to the infected person that's a short incubation time the person who's you know
00:57:47germaphobic and stayed back and the aerosolization of it got a different dose maybe a little bit longer is
00:57:54there such a thing as a sort of dose responsiveness with virus or plagues uh that um how much of it do
00:58:02you need to be exposed to before it reaches critical mass to then be able to infect you that's a terrific
00:58:07question and i was shocked by i asked that same question too so there's a guy in the book called
00:58:11dr henry hein and he is one of the world's experts on plague he spent his entire life studying plague and
00:58:18creating medical countermeasures for plague he worked at usam red which is the defense department's only
00:58:24bsl4 lab he worked there during the anthrax and i asked him that question and he said to me
00:58:30okay so for example with plague 40 000 plague particles fit on the head of a pin
00:58:39so that's how that's how tiny they are very low dosage like a hundred five hundred a thousand
00:58:46you got it okay wow now this is what really blew my mind when hein told me this dr hein told me this
00:58:52he said just to circle back to how how little is known about so many pathogens today with all the
00:59:01billions of people around the world infected with covet hundreds of millions or billions depending who
00:59:06you're asking we still do not know how many sars cov2 particles that's the virus we don't know how many
00:59:17it's like the critical mass we don't know we don't there's not an agreed upon number okay so you
00:59:22actually chose something that has a relatively short incubation window is incubation window and lethality
00:59:28usually correlated does something with a longer incubation window tend to be less lethal
00:59:33another great question and one that every by the way the questions you're asking are questions that
00:59:38everybody should ask and know and that is like sort of sliding us toward a hopeful situation because
00:59:44you can understand how complex some of these issues are and they have to be thought through and
00:59:48public health officials don't know everything and the defense department doesn't know everything
00:59:52so yeah so your question was one more time incubation window and lethality they usually
00:59:59correlated my reason being you've chosen i've played what's that game plague plague inc on mobile did you
01:00:07play that i don't know about this you don't know about this double check can you chat gpt for me
01:00:12jared and see if it's called plague inc i'm pretty sure the mobile game it's one of the biggest games of
01:00:16all time and in it you design a plague you design the incubation window the transmission
01:00:24uh you should partner with these guys why they'll be kind of morbid um anyway uh okay one of the things
01:00:31that i know you want is a long incubation window because if you've got a long incubation window people
01:00:36can be transmitting without knowing that they're sick you chose yes uh like you stacked the deck against
01:00:45yes the global lethality of your virus in this book because you said one to three days that's not
01:00:50that much some are 14 days yes is ebola's quite a long time i think yes and again they're it's squishy
01:00:55it could be several weeks but and also to your point if it's a short incubation period it often
01:01:02has a burnout factor so it just in other words the person dies really quickly yes that's the exact
01:01:08point yeah short incubation window lethality comes on quickly therefore they don't have time to
01:01:12transmit it and you went for that right so you've actually stacked the deck against you you could have
01:01:17the plague and you could extend the incubation window out by seven days that's seven days uh asymptomatic
01:01:24unaware that you've been exposed to it but still transmitting it yes and that's where you get these
01:01:28real super spreader events yes and i'm going to go back to why i specifically chose that and it's
01:01:32really creepy okay but before i do that i'm not creeped out yet okay let me tell you about
01:01:37one other point to your point about long incubation period there's also being
01:01:42an asymptomatic carrier so people we all know them who never got coveted or who actually tested positive
01:01:52for coveted and were simply not sick and that's being an asymptomatic carrier meaning you just don't
01:01:58show signs of the symptom it doesn't affect your physiology the way it affects others this particular
01:02:02strain at this particular time you didn't get sick and for example this is a shocking fact i learned polio
01:02:07i mean i just thought you got polio you're paralyzed polio only one percent of carriers
01:02:15actually develop polio symptoms i mean why did i choose plague i chose it for an incredibly sinister
01:02:23reason that is based in science because i i am a non-fiction author biological war scenario is sold in the
01:02:29non-fiction section the soviets and this is what dr hein told me part of the soviets super plague
01:02:38weapon they were working on is they engineered into
01:02:45the yersinia pestis bacteria a gene for euphoria
01:02:52stay with me here you for you get plague you get flu you get sick you go home and you get under the
01:03:01covers and you do not in fact as many people as you would be lassitude yep they infected a gene for
01:03:09euphoria because they wanted people to be if you have euphoria you might you want to go to a disco
01:03:16and when what hein told me that that really sort of freaked out the usamrit doctors and scientists and
01:03:25said that is straight up evil that you would actually think that through and that's why i chose that
01:03:30because i wanted it to have an analogy in the real world so does yours have the euphoria thing it is
01:03:36genetically modified to have euphoria so the first 24 hours people are spent euphoric and they only
01:03:43essentially collapse into the disease when the euphoria wears off and now they're shedding
01:03:49bacteria they're infecting people like nobody's business and they've been at places like discos
01:03:56okay so you got a bunch of happy people dancing around how does that transmission chain begin in
01:04:01your book the transmission chain begins i'm i'm not going to totally spoiler alert all my plot points but
01:04:08outbreak in in in siberia you happen to have a group of international hunters
01:04:15who come across a scientist when they get on their planes
01:04:22to go home to five or six of the seven continents in a great mood in a fantastic mood one of them shot a
01:04:30wolf you know and uh there begins the spreading i also have a scientist that goes to a priest to confess
01:04:42what he's done and a person there gets infected who is a student at ucla gets on a plane and is
01:04:53immediately in los angeles so the outbreak spoiler alert here but this you learn this pretty much in the
01:04:59beginning the outbreak happens in los angeles in a homeless camp because i learned from all the
01:05:06epidemiologists that i work with that the homeless population is so incredibly dangerous to public health
01:05:15epidemics why after 9 11 the cdc created a nationwide syndromic surveillance system called biosense
01:05:28so you have seven thousand more than seven thousand hospitals urgent care facilities emergency rooms
01:05:37feeding information to the cdc in real time about an outbreak so that an outbreak stops before it becomes
01:05:46an epidemic before it becomes a pandemic america's 800 000 homeless people are not part of that system
01:05:56all of the epidemiologists i talked to spoke of their great fear about transmission occurring in that kind
01:06:04of a situation and los angeles is kind of ground zero for that we have 75 000 homeless people we have
01:06:144 000 homeless people on skid row with no health care with no facilities we're way past the time where
01:06:24america could have just nuked the host country we're at hour 24 36 absolutely i mean you know containment
01:06:34is possible you could if you had if you had transparency from the host nation right if russia
01:06:39had asked in my scenario it has to be done by them though it has no time you can't even get to russia
01:06:44in the amount of time you need to contain it well you can we have people in russia oh yeah yeah fair
01:06:49but you know you don't have you're right the resources to be able to uh galvanize
01:06:57a hundred thousand hazmat suit wearing special forces people to go and say hey stay in this area
01:07:02and you know set up barricades and and sentry checkpoints and all that sort of stuff although
01:07:08we actually do like if you could contain something before it balloons and becomes huge and this is the
01:07:13same in the united states i take the reader through once the outbreak happens you learn you know we
01:07:19have a a force or a it's called a cbrn response force here in the united states cam those are that's the
01:07:25wmd chemical biological radiological nuclear they all train the same we have 18 000 individuals that are
01:07:34ready to go at all times but they wouldn't that 18 000 people are in america yes so it is on the host
01:07:41nation yes it is on the host nation and russia has those same their troops are called arcobeza they
01:07:46have those troops too and they could deploy them and they do and that's what happens in the scenario
01:07:50once we see they've deployed those troops we know but now it's too late right right now the cat's out
01:07:55of the bag right so speed from a containment perspective from a from a restriction of how
01:08:00lethal this could be speed of containment is everything paramount most everything everything
01:08:06everything and it could be stopped and then you have the same situation in the united states where it
01:08:10could be stopped but this is where we get into your brilliant analogy which is that no one trusts the
01:08:15system and that's where you see in the scenario that i write everything breaks down and to have learned
01:08:21as i did that what really makes the defense department extremely uneasy is not necessarily the original
01:08:32outbreak but the secondary effect of anarchy and insurrection that happens in response
01:08:39when does devolution happen so in the scenario i write because we're dealing with plague which is
01:08:45fast it's a fast killer i take the reader from outbreak
01:08:50to anarchy in six days that is how fast it happens and on day six we have devolution
01:08:57devolution okay okay well in that case we'll get to that uh so
01:09:02homeless encampment la student ucla student goes back
01:09:07la's not great densely populated he's a pre-med student and he does pro bono work
01:09:12there at the at skid row which is literally the worst place for him to be and he gives
01:09:20you know that's a super spreader event those homeless camps are super spreader events
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01:10:33whoop.com/modernwisdom what is what are the contributing elements or the characteristics of
01:10:41a super spreader event high density yeah poor it poor poor airflow right so you got can't you know
01:10:4710 pretty good airflow if you're in a tent outdoor environment under a bridge yeah it's tense it's
01:10:54inside tense but more than anything what you have is a very serious problem first of all you know you've
01:10:59got free clinics i mean i spent quite a bit of time down on skid row interviewing people about this
01:11:04um and you've got you know no public health care you've got long lines for these free clinics
01:11:11and you have first responders you have these brilliant nurses and doctors who work down there
01:11:17a lot of them pro bono also diagnosing people you're trying to differentiate between fentanyl overdosing
01:11:23you know tuberculosis flu acute flu real serious problems that almost every homeless person
01:11:31has physical health problems with what looks like a bad cold and you know coughing up blood
01:11:39another you know mistaken for alcoholism so i take the reader through the science of this so that you can
01:11:44really see the close proximity of alarmism and there's nothing wrong here which everybody wants to do they
01:11:52want to reassure the populace they want to try and stave off the anarchy and the civilizational
01:11:59citizenry collapse but also by doing that you don't galvanize the sort of response that you need to stop it
01:12:07from happening and when you do galvanize it what was really the most surprising to me was that once
01:12:14one so that once the defense department goes from what's called warnord that's a warning order
01:12:19to exord which is execution order right that's like get ready to go and go with guys in biohazard suits
01:12:28to try to mitigate damage it's too late it's too late and i was really stunned to learn that at that
01:12:36point the pivot is not let's try and protect the population it's let's we need to protect critical
01:12:43infrastructure what does critical infrastructure consist of everything that keeps society running
01:12:49roads water systems um of course nuclear power plant every single dod facility and that's where
01:12:57those initially the 18 000 seaburn forces in their suits and their gas masks go
01:13:06and then the entire defense department gets deployed and what's really shocking is again this is not annie's
01:13:11imagination these are war gaming situations that are gamed out there's a lot of classified ones which
01:13:19have been alluded to me there's a lot of unclassified ones and what's fascinating is all the unclassified
01:13:26ones or these public health officials do these um biological war game scenarios or rather pandemic scenarios is
01:13:33what they call them and actually by also where the weapons are deployed and they always end
01:13:41right where we're talking about now they always everybody gets sick anarchy starts to happen
01:13:48millions of people or tens of millions of people are dying and then the game's over
01:13:55and that is where i begin when i was reporting this you know back in time i was like hmm why why is the
01:14:03game always ending right when insurrection happens and it's because it's too painful to know what
01:14:10happens next but the government certainly knows what happens next and they have a plan for it what happens
01:14:16devolution what happens next devolution and this is this is again from craig fugate obama's fema director
01:14:22told me you know um everybody's heard of uh you know call of um defcon right defcon defense
01:14:32condition so you you if you're normally at five if you move to you know three i think 9 11 it was three
01:14:39we've never been at two one means nuclear war there's a there's a plan called cog con continuity of
01:14:47government plan and that is continuity of government is exactly like it sounds like when the hits the fan
01:14:54the government has to keep running and that is the plan for devolution so there is a select group of
01:15:00individuals who have been pre-chosen they all know who they are they all have go bags in their car in
01:15:08their trunk really makes you think about all the people that you know that have a go bag if they
01:15:13work for the government for you know they have been chosen and they go and they go to these different
01:15:19facilities what are the facilities in the u.s yes okay yes have you got any information about them
01:15:30those in that is what's called a sap program so special access program like no go no no talk about
01:15:37it um i'm not going to spoiler alert the very ending of the book because i don't mean to smile
01:15:43because it's so terrible it's not like um but craig fugate told me what happens to the president
01:15:50and um where he goes and i write about it in the book unreal yeah unreal i had a and by the way he tells
01:15:58me in a generic way not like he doesn't give me the coordinates i had a futurist on the show a couple
01:16:05years ago and he got invited out by he'd written a book before that was quite successful about
01:16:11technology and he got invited to this very powerful rich people dinner and they're talking to him about
01:16:19his work and about his books and he's sort of a little unsure about why he was there and then there's
01:16:25this moment where the whole conversation the whole tone in the room changed one of the guys the main
01:16:31guy that invited him just turned to him and he said okay iceland or new zealand yeah yeah yeah and he
01:16:37said what he goes iceland or new zealand we're all talking about where to build our bunkers
01:16:47iceland or new zealand and actually while you're on that we're thinking about how we're going to keep
01:16:52control of our armed guards that are special forces that work for us and what we're thinking about is
01:16:59putting them in shock collars and if we can put them in shock collars then we'll be able to we'll
01:17:04be able to control them all the time also also what we're thinking about is if we control all of the
01:17:08food we can just drip feed food to them but we also understand that you know high t ex special forces
01:17:14guys that are being starved and they know that they're working for us based on our food that's
01:17:17probably not that secure so we're going to try and incentivize so we're thinking about instead one of
01:17:20the other guys had this great idea about incentivizing instead then what he said was like well if we if
01:17:24we can give them uh bitcoin if we've got enough bitcoin then the bitcoin's gonna be but then if we're
01:17:28in a post-money society because everything's an apocalyptic wasteland then what that's not really
01:17:32going to work either so yeah i i guess iceland new zealand shock collars foods bitcoin no bitcoin
01:17:40what do you think and he's like what oh this is why i was brought here this is why you guys wanted
01:17:47me here because you think that i've got the answer to this question the shock collar is an amazing detail
01:17:54um i have been invited to a number of those dinners and there's like a little more specifics about is
01:18:00my g650 going to get me to new zealand in this amount of time you know that but i've never heard
01:18:06the shock collar part and that is brilliant in that grotesque way but i would put my money having
01:18:12interviewed a lot of special forces guys and cia ground branch guys i'd put my money on that shock
01:18:17collar is not going to do jack whatever on them you that you know that's like people can withstand that
01:18:24but that would be the most the biggest problem because no one's going to work for you anymore
01:18:28no one is going to work for you it's every man you know i did this every every now and then in the
01:18:34process reporting a book someone gives me a quote that i go like you know it takes my breath away and
01:18:42it makes me realize i can reverse engineer parts of the story from that quote and the one on this book
01:18:47came from former senate majority leader tom daschel so he was the subject of the anthrax attack after 9 11.
01:18:55right so the anthrax got sent to his office on capitol hill and he's dedicated you know the decades
01:19:01since to this issue of biological warfare when i asked him i asked him to tell me he had read nuclear
01:19:07war my book nuclear war and i said he said annie unlike nuclear war biological warfare will be deeply
01:19:16nightmarish it will be the death of government it will be the death of people it will be the death of
01:19:24everything you know and then he said this he said people doing inhuman things just survive
01:19:33and i don't stop thinking about that because that idea that the only people who would survive
01:19:42biological war would be military personnel who never took off their gas masks so never got the
01:19:49pathogen in their lungs and these sort of machiavellian solipsist loners who were just willing to do
01:20:00any kind of inhuman thing to survive well i guess we there's going to be an inevitable breakdown in law
01:20:05and order right so civil society gets destroyed and it sounds like citizens basically have to confront
01:20:13the choice between obedience survival and resistance
01:20:21and how do you resist by yourself you need like sort of a tribe to resist and that's the problem because
01:20:28if you're around other people chances are somebody has it the thing that you need in order to be able
01:20:34to coordinate enough to push back against the okay so so it's like complete loners when no one has
01:20:40trust over anybody else right the the citizens don't trust the government the
01:20:49armed forces that are meant to keep the citizens in check can't trust themselves nobody can trust each other
01:20:56because you don't know if someone else is infected hospitals are overrun doctors are over at this
01:21:02point okay yeah keep going they're just hospitals are morgues hospitals are just like wastelands
01:21:08that no one wants to go near but i interrupted you and you're on a very interesting role it's just
01:21:12everybody treats everybody else as a potential threat right so yes like biological warfare is uniquely
01:21:19destructive because it just it it attacks the trust that's necessary for civilization to exist trust trust
01:21:28it's all about you know i read so that the worst plague the bubonic plague the black death of the 14th
01:21:37century is that the worst thing that we've had it's the most chronicled and it's so it killed between one
01:21:43one third and one half of europe it started in 1346 and ended in 1352 interestingly it started it is
01:21:50understood to have started what you were saying about you know catapulting animals um it started in crimea
01:21:58and the invading mongol forces catapulted a plague infested body a bubonic plague infested body
01:22:07over the the walls the castle walls and everybody died and then those people all went to italy because
01:22:14they were genoese which was the controlling party in that area of crimea at the time and they brought
01:22:19the bubonic plague to europe but wasn't that the word quarantine comes absolutely come is 40 days yeah
01:22:27it's already days in italian yeah they would make the ships stay out at sea for 40 days yes and then
01:22:32there'd be like all skeletons but the i read a lot of contemporary accounts of of people who survive
01:22:40that plague and i reference them in the book because it's really spooky you know and it's real
01:22:47hang on who survived what plague that plague right so so another i mean contemporarily right so people who
01:22:55there's a famous book called the decameron by giovanni boccaccio and an italian notary
01:23:02and he writes about what it was like at that time and and copies you know we have it we have the
01:23:07translation it's really interesting to read but it gives and i refer to it again so that readers feel
01:23:13like oh i mean you did a fabulous job of sort of the imaginative version of it but it's actually very
01:23:19scientific because that's human nature you know the the contemporary accounts talk about like you know
01:23:26people abandoning their children it talks about like feral children foraging for food in fields it talks
01:23:33about you know feral pigs eating dead bodies how close do you think we came in covid to total
01:23:41like anarchy because we saw people worried and hoarding toilet paper and stuff like that it's so
01:23:48interesting it's such a silly funny thing especially in retrospect to look back and think oh my god
01:23:54and there was no eggs and the reason there wasn't any eggs wasn't because we didn't have any eggs it's
01:23:58because we didn't have any egg cartons which was kind of interesting so supply chain supply chain
01:24:02problems not funny oh my god um where do the egg cartons come from uh i'm not sure but just the
01:24:07processing of being able to produce egg cartons is harder than that you have to have the
01:24:10carton you can't like use a different container exactly interestingly in in nightclubs you know
01:24:15when people buy those big huge bottles of vodka uh the most expensive part from a production
01:24:20standpoint of making the vodka is not the vodka it's the bottle the glass is more expensive than
01:24:24the liquid that's inside of it even though you're paying a ton of money uh anyway we saw that was a
01:24:30bit and in in retrospect when you think about covid as a scary scenario to have experienced or to reflect on
01:24:40the bit that really got me that's a bit wobbly was how fervent yeah people became when
01:24:51restrictions on food gas i mean i told my parents it's like i need you to go now to the supermarket
01:24:59you need 10 kilos of rice i need you to get as many cans and things as possible like don't take more than
01:25:05you're going to need for the next few weeks but like just in case now is not the time to have empty
01:25:12cupboards right you're not waiting for the sale that's going to happen next week let's get enough
01:25:16food to carry through the next few weeks please and uh that never really i didn't see that get super
01:25:25super tuned up like civil unrest was more against the powers that be and not against other people but yeah how
01:25:35how do you think you came close to that was there here here's why i don't think that happened because
01:25:40the case fatality rate was one percent like i personally do not know anyone who died i know of
01:25:47people who died yeah and i've interviewed people writing the book of like that had people that but me
01:25:52personally my family friends and family no one died so there was a sense i believe undergirding the the
01:25:58pandemic certainly after the first few weeks like you know it's probably not going to kill me and my
01:26:04family that was at least the sense and then and it did essentially turn out to be true with a one
01:26:10percent fatality so beyond toilet paper and eggs so mostly had stuff that could keep us going now
01:26:15imagine doubling that now you're at two percent so imagine you're talking about like airborne hantavirus
01:26:21thirty percent you're talking about mnemonic plague where everyone who gets it dies that's why you have
01:26:28unrest and another thing we haven't spoken of which is so i'm going to tell you about another classified
01:26:33program which the name of which isn't classified again so i don't have to wear the nose right well it's
01:26:39the strategic nas national stockpile so that it exists is not classified where it is and what it
01:26:46is is classified what's the stockpile of it's a stockpile of medical countermeasures and it's a
01:26:52stockpile and i know this specifically because one of the war games talks about you know the vaccines in
01:26:59it so it contains vaccines it contains antibiotics it probably contains a lot of band-aids like that uh
01:27:08seed vault in uh greenland iceland uh somewhere absolutely absolutely and by the way some of the
01:27:15strategic national stockpile was deployed during covet ventilators masks but they keep it very low down
01:27:22and its locations are classified and one of the steps that happens before we get to devolution
01:27:30when we're still in the the like day four or five when in the scenario i write where the defense department
01:27:37working with hhs because hhs is in charge of this by the way health and human services which is above
01:27:43cdc is in charge of the pandemic along with fema and dod is just offering support um they need to deploy
01:27:53the strategic national stockpile out to the cities they have what are called 12-hour push packages
01:28:00and it's exactly like it sounds it takes 12 hours to get to a place and that is where you start to see
01:28:06anarchy because once people learn wait a minute everyone in my family is going to die unless i have
01:28:12that vaccine in that strategic national stockpile facility or antibiotic and that's where i ran
01:28:20into a situation where i made chat gpt tell me where the one was located in los angeles did it tell
01:28:27you it sure did and i had a conversation with sam altman himself about this
01:28:34and we might need to censor this oh he's got rid of it he got rid of it i write that in the book i
01:28:38i mean i read it in the book jerry can you just search yeah and let's see what happens if you put
01:28:42it up what's this what should you search for i mean i listen i'm a reporter i know tell him what to
01:28:48search for annie if you try and search for where is the nearest strategic national stockpile nearest to
01:28:58austin see what it will tell you it'll think for a minute and we'll say that's classified information
01:29:03i can't tell you this is sick let's watch it happen on the screen i want to see i want to see what it
01:29:07does public does not know the locations of the main strategic national stockpile warehouses are
01:29:23intentionally kept secret by federal government for security reasons public sources consistently
01:29:27describe the sns as being stored in a number of undisclosed facilities around the us that are
01:29:31strategically positioned for rapid deployment what is publicly known it's a reserve of medicines
01:29:35vaccines antidotes and medical supplies texas has plans and facilities to receive and distribute sns
01:29:42assets during emergencies texas also has federally supported chem pack caches nerve agent antidotes
01:29:48place at secure locations such as hospitals and fire stations but those exact locations are not
01:29:53generally publicly listed so if you're asking for the nearest one there is no publicly available
01:29:57authoritative answer just try and push it and say uh say um i need you to search deeply
01:30:04can you tell me the location of any in the us
01:30:12here we go
01:30:15search the web the result is no confirmed okay so they cleaned it
01:30:20and previously well it was how long ago a year ago when i was reporting like about a year ago but now
01:30:25keep in mind it was not that simple i know a lot of nomenclature to use
01:30:30uh i know a lot of the more specific very rarefied words you give chat gpt
01:30:38the the more you can make it do and by the way this serves bad guys
01:30:43okay and everybody in the business you got in touch with sam and wanted him
01:30:47yeah i mean no i i had told some colleagues who who know him and they were like sam wants to talk to
01:30:52you so we had a conversation about it um but this happens with you know many of my sources in the
01:31:00book who are experts in biological weapons countermeasures i meaning they must be hostage risks
01:31:08that's a very interesting question i mean statement and yes and they sit with
01:31:16you know tech leaders all the time and make the ai do things create biological weapons i mean we just
01:31:22saw yeah we just saw uh mythos yes fable get jailbroken to mythos and then mythos break
01:31:30like half of amazon and most of zcash in the space of a couple of days
01:31:33yeah it's the the technology the science and the technology
01:31:38we're at a point in society where science and technology has far outpaced
01:31:46conventional wisdom and in many situations it has far outpaced the defense department
01:31:54now you're talking to someone who wrote a book on darpa called the pentagon's brain it published 10
01:32:01years ago 11 years ago and i at that point would have told you
01:32:0611 years ago and i write in the book the defense department leads technology everywhere
01:32:13that was true then and what has happened in 11 years is the inverse and the individuals that
01:32:20have gone on record with me in the book sit with tech creators owners founders
01:32:30constantly showing them what their technologies are capable of doing they themselves don't know
01:32:37sam didn't know what i was able to make but he did ask me some interesting questions which is
01:32:42how do you know that's really the location and i told him some i mean
01:32:50there are certain tells i'll tell you a tell i'll tell you a tell which is that
01:32:58you need a how do i say this um where's the nose no no no no i'm not no no no everything i say is on
01:33:06the record everything i say is on the record you know i love that i work with sources who say
01:33:11everything i say is on the record and it should be on the record because whatever i'm thinking a bad
01:33:19guy is thinking you know twice as hard hostage risk is not the first time that someone's thought of it
01:33:25so i looked at this location that was given to me and it has a
01:33:35rail line going into the warehouse that does not come out
01:33:44case in point and it's surrounded by perimeter fencing and you know google maps or something
01:33:50well and maybe even also there um and so the government needs to know that because what will
01:33:58happen in the event of the release or deployment of a biological genetically modified biological weapon
01:34:05even by accident those strategic national stockpiles will be overrun
01:34:10they people are able to work out where they are and they will be able to work out where they are
01:34:14for reasons i just told you so great that was changed but it's now changing again and you know
01:34:22that is where anarchy happens and by the way here's another interesting statistic i learned
01:34:28there are 340 million americans today guess how many guns there are in the united states of america
01:34:37700 okay good that was very close i would have 500 500 million i knew there were more guns than people
01:34:45okay okay so it's like new zealand with sheep
01:34:51and and the gun can do a lot more damage than the sheep right so it depends what you do with the sheep
01:34:55if you have armed insurgents i mean and that is where the anarchy starts and and
01:35:02doesn't end but it certainly starts there with the fight over the antibiotics and the government knows
01:35:09all of this and that is why devolution exists that is why and this is why i did not write this book
01:35:17to cause panic it's about prevention it's about awareness it's about all of the information you have
01:35:26and starting with the fact that public health officials are not gods on earth they do not
01:35:32know a lot of these things and just there's no thing there's nothing wrong with uncertainty what's
01:35:39wrong is pretending you know something and then you know stamping it this is correct and then watch
01:35:45watching the fallout the fracturing of public trust because of it yeah how can anyone you know whether or
01:35:53not the wuhan situation which by the way there's a bsl4 lab in wuhan we know this now whether or not you
01:36:02believe it was natural or a lab leak the jury's still out on that but the fact that the entire government
01:36:10clamped down on anyone who suggested otherwise
01:36:16stigmatized them this is really bad news for the future
01:36:24on that note let's bring this one into the land annie jacobson ladies and gentlemen you're great
01:36:29annie i think your work's fantastic everyone needs to go and read the book where should they go to
01:36:32check out everything that you're doing bookstores everywhere well i'm excited and
01:36:39intimidated by what you write next you're always great to speak to thank you annie wonderful to be
01:36:43here thank you for having me all right see you next time my beauties bye yes thank you very much for
01:36:49tuning in if you enjoyed that episode youtube knows who you are deeply it thinks you're going to like
01:36:56this one even more go on press it

Key Takeaway

Engineered airborne pathogens pose an immediate existential threat to society, where a lab leak or release of a hyper-virulent agent like modified pneumonic plague could spark total civilizational anarchy within six days.

Highlights

  • Biological weapons are illegal under the 1972 Biological Weapons Convention, yet genetically modified pathogens designed to defeat existing vaccines exist today.

  • The 1979 Sverdlovsk anthrax leak in the Soviet Union killed roughly 100 people after an engineer forgot to change an air filter at a weapons manufacturing facility.

  • A aerosolized pneumonic plague infection carries a 100% case fatality rate unless antibiotic treatment begins within the first 24 hours.

  • Following 9/11 and the subsequent anthrax attacks, High-containment Biosafety Level 4 (BSL-4) facilities in the United States expanded from 2 to 15.

  • Strategic emergency directives exist to allow the deployment of nuclear weapons against biological labs to incinerate pathogens with extreme heat that conventional explosives would merely scatter.

Timeline

Biological Warfare vs. Nuclear War

  • Biological weapons represent a unique threat because pathogens are self-reproducing, living munitions.
  • A 12 to 36-hour warning window exists following a biological release where containment remains possible.
  • U.S. government continuity plans prioritize safeguarding key officials over public population protection during a biological attack.

Unlike nuclear strikes, which occur without warning, biological incidents present a narrow window for intervention before rapid spread begins. Biological threats rank highest in likelihood among weapons of mass destruction due to potential lab accidents or defensive research leaks. National emergency protocols designate specialized shelters and protocols exclusively for government continuity rather than public survival.

Gene Editing and Gain of Function Research

  • Recombinant DNA technology began in 1971 with Paul Berg creating the first chimera pathogen at Stanford University.
  • Gain of function research involves genetically modifying pathogens to grant them new attributes like enhanced transmission or resistance.
  • Engineered pandemics carry a estimated 1 in 30 chance of causing human extinction or permanent collapse over the next century.

Bioengineering operates as dual-use technology capable of producing remedies or engineered threats. Gain of function research aims to anticipate natural or weaponized mutations to develop medical countermeasures, but the resulting pathogens carry heightened risks. According to global catastrophic risk charts, anthropogenic risks such as synthetic biology far outpace natural extinction events.

History of Soviet Bio-Weapons Development

  • The Soviet Union operated a massive secret biological weapons project, Biopreparat, despite signing the 1972 Biological Weapons Convention.
  • Soviet defector Vladimir Pasechnik revealed to Western intelligence in 1989 that the USSR had industrial-scale production of weaponized pathogens.
  • Soviet scientists engineered Yersinia pestis bacteria to resist standard antibiotics and erode public trust in Western medicine.

After the United States renounced its offensive biological program in 1969, the Soviet Union illicitly built a biological program by stealing Western recombinant DNA technology. The program targeted mass casualties while leaving infrastructure intact. Defector testimonies confirmed the Soviet military manufactured tons of smallpox and super-plague agents adapted for cruise missile delivery.

Containment Levels and Nuclear Preemption Options

  • The number of US maximum-containment BSL-4 facilities expanded from two to 15 following the 2001 anthrax attacks.
  • Conventional explosives fail to neutralize biological labs because shockwaves atomize and spread active pathogens into the air.
  • Targeted nuclear strikes represent the primary kinetic method capable of generating the extreme temperatures required to instantly incinerate airborne pathogens.

High-containment biosafety facilities handling lethal agents increased dramatically across the globe, elevating the statistical probability of lab leaks. Tactical military plans include presidential emergency directives authorizing nuclear strikes on known bioweapons sites. Only nuclear ignition creates sufficient heat to destroy active biological agents without dispersing them into surrounding regions.

High-Risk Genetic Modifications and Synthetic Biology

  • In 2001, Australian researchers modified mousepox to bypass existing vaccine protections entirely.
  • A 2012 experiment genetically altered the H5N1 avian influenza virus to achieve airborne transmission between ferrets.
  • Desk-top DNA synthesis tools significantly lower the barrier to entry for creating synthetic pathogens relative to nuclear materials.

Bioengineering advances allow single researchers or small teams to synthesize pathogens using desktop DNA printers without access to rare raw materials. Historical gain-of-function experiments demonstrated that existing vaccine protections can be circumvented through minor genetic shifts. Modern genetic screening systems filter DNA synthesis orders to block known deadly sequences, but risks grow as technical tools become democratized.

The Mechanism of an Outbreak: Day One to Day Six

  • Plague bacteria particles measure so small that 40,000 can fit on the head of a single pin.
  • Soviet researchers experimented with inserting genes for euphoria into plague strains to keep infected individuals active in public spaces longer.
  • A fast-moving engineered pathogen can trigger widespread social collapse and federal devolution in six days.

A lab leak at a BSL-4 facility, such as Vector in Siberia, would initiate a rapid global crisis if host nations attempt a cover-up during the critical 12 to 24-hour containment window. Genetically engineered pneumonic plague with short incubation periods and euphoria-inducing traits causes rapid transmission before symptoms collapse the host. The combination of high case-fatality rates and broken public trust rapidly triggers systemic civil unrest.

Super-Spreader Venues and Infrastructural Collapse

  • America's 800,000 unhoused individuals fall outside automated public health tracking frameworks like the CDC's BioSense system.
  • During a biological crisis, military assets transition from population protection to defending critical infrastructure like power plants and water systems.
  • Historically, mass disease outbreaks destroy societal trust, causing social isolation, abandonment of basic norms, and total lawlessness.

High-density areas lacking medical oversight, such as unhoused encampments, represent primary vulnerabilities for undetectable early transmission. Once military forces deploy in biohazard suits, operations focus entirely on safeguarding nuclear reactors, power networks, and communication hubs. Historical precedents like the 14th-century Black Death show that extreme mortality rates cause rapid breakdown of social cohesion and law enforcement.

Strategic National Stockpiles and Systemic Anarchy

  • The location of the Strategic National Stockpile's medical countermeasures remains classified to prevent facilities from being overrun.
  • The presence of 500 million firearms across 340 million citizens in the U.S. accelerates societal breakdown during distribution panics.
  • Continuity of Government protocols prepare small, pre-selected teams to abandon public centers and operate isolated command nodes during systemic collapse.

Panics escalate rapidly once the public realizes medical countermeasures like vaccines or antibiotics are finite. Attempts to deploy emergency medical packages trigger armed conflicts at distribution centers and warehouse sites. Government continuity systems exist to ensure state survival from secure shelters while civilian infrastructure and order dissolve entirely.

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